We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Ondansetron HCl?

Tricia Christensen
Updated Feb 19, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Ondansetron HCl is an antiemetic drug, used to treat nausea or vomiting resulting from severe illness, such as food poisoning, and medications that may cause vomiting, like opioids, anesthetics, and chemotherapy drugs. The medication was developed by GlaxoSmithKline® in the 1980s and many markets had access to it by the 1990s. Like all drugs, ondansetron HCl can have side effects and drug or medical condition interactions, but it is considered very effective.

There are several different ways ondansetron HCl can be delivered. It is available by prescription in pill and liquid forms. Some of the pills can be used sublingually or under the tongue, and they may start working within a few minutes of use. The drug can also be injected or used in an intravenous drip. The maximum dosage per day is 8 milligrams, though many physicians now believe that a single dose can prevent vomiting for a full day.

The conditions for which ondansetron HCl is used are varied. It is considered exceptional in its prevention of vomiting in patients undergoing chemotherapy or reacting to very recent anesthesia. It also appears to help reduce nausea or vomiting in people who must take pain medications likely to cause it, like morphine or hydromorphone.

Patients who come to hospitals with severe vomiting due to food poisoning may benefit from this drug. There is more debate about its use to treat conditions like seasickness or labyrinthitis. Some patients find it helpful for these conditions, but others benefit from a different antiemetic.

Some side effects of ondansetron HCl can be classed as mild. The drug may cause constipation or tiredness, and some patients feel dizzy or lightheaded when they take it. Patients don't have to report these effects unless they become bothersome. In contrast, doctors need to be notified immediately if patients develop spasms in the muscles, pains in the stomach, or changes to eyesight.

A few very rare, but medically emergent, side effects of ondansetron HCl exist. If patients notice severe dizziness, heart rhythm changes, or chest pain, they should get emergency help. Some patients may be severely allergic to the drug and should get medical treatment immediately if they develop hives, difficulty breathing, or swelling of the lips, face, and tongue.

This medication may interact with a few drugs and substances, including any that block production or release of serotonin. It is not advised people take ondansetron HCl with apomorphine, tramadol, or alcohol. Patients should review a list of all their medications with the prescribing doctor to rule out any other interactions.

Certain physical conditions may contraindicate the use of ondansetron HCl, too. People with stomach disorders, recent stomach surgery, or kidney disorders may have difficulties with this drug. Studies on whether ondansetron is safe for use in pregnant and nursing women aren't available. The medication should be avoided or used with great care in this population.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Tricia Christensen
By Tricia Christensen
With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia Christensen is based in Northern California and brings a wealth of knowledge and passion to her writing. Her wide-ranging interests include reading, writing, medicine, art, film, history, politics, ethics, and religion, all of which she incorporates into her informative articles. Tricia is currently working on her first novel.
Discussion Comments
Tricia Christensen
Tricia Christensen
With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia...
Learn more
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.