We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Epitestosterone?

By Misty Wiser
Updated Feb 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Epitestosterone is a male steroid hormone very similar in molecular structure to testosterone. Males and females produce this hormone naturally when testosterone is metabolized. Large doses of it have been used to cover up the illegal use of other steroid hormones in professional athletics. The normal result for the ratio of epitestosterone to testosterone in the body is close to 1:1. Olympic athletes must stay under a 4:1 limit, and professional football players must be under a 6:1 ratio to avoid being penalized.

Some people take anabolic steroid hormones to improve their athletic performance and to shorten the time it takes to build muscle mass. The excess steroid hormones can cause the overgrowth of body hair and also cause the voice to deepen in tone over time. A male may notice a decrease in the size of his testicular tissue as a result of anabolic steroid use. Athletes that take these steroids will need to disguise their use when tested.

The test to determine the ratio of epitestosterone to testosterone is performed on urine samples. A laboratory will do a gas chromatography to show the ratio of the two hormones. Much higher amounts of epitestosterone than testosterone generally indicate an artificial use of anabolic steroid hormones, since the naturally occurring hormone is commonly injected to disguise the presence of steroids in the urine.

A more sensitive test called a high performance liquid chromatography/tandem-mass spectrometry (HPLC/MS) is sometimes used when the results of the first test are called into question. Some athletes have maintained a metabolism issue indicates a false positive, as opposed to the illegal use of steroids. The HPLC/MS is able to differentiate between masking the use of a steroid and a metabolic issue that may cause elevated levels of the natural steroid hormone.

Use of epitestosterone is not proven to increase muscle mass or improve athletic performance. It is an inactive epimer of testosterone, and is usually injected to hide the use of anabolic steroids. The natural steroid is not metabolized by the hepatic or renal system, and therefore has very little effect on the healthy body.

Naturally produced large doses of epitestosterone have not been shown to have any adverse side effects. Levels of the steroid hormone stay consistent throughout middle adulthood. Most adolescents have the highest level of epitestosterone when tested. The amount of the hormone naturally produced by the body will decrease with age, as testosterone production decreases.

A few supplement companies sell a cream made of epitestosterone and testosterone. The cream is applied to the skin to allow the steroid hormones to pass through the epithelial tissue. It was designed to be less detectable in urine tests, allowing for its use among those that are regularly tested for performance enhancing substances.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.