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What is C-Reactive Protein?

Mary McMahon
Updated Feb 05, 2024
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C-reactive protein (CRP) is one of the many proteins which can be found in human blood at varying levels, depending on someone's health. Evaluating levels of C-reactive protein may be a part of diagnosis of disease, and monitoring of CRP levels can also play a role in determining how well a patient is responding to a particular medication. Laboratories which handle blood can determine the level of protein in the blood by using a special test which may be used upon a doctor's request.

This protein is produced by the liver and the fat cells in the body. The body makes this kind of protein in response to infection, which means that elevated CRP levels can suggest a systemic infection. The concentration in the blood tends to rise with the severity of the infection, reaching a peak and then declining as the body breaks the protein down once the infection has been dealt with. Medications used to manage systemic infections and inflammations should cause a decrease in CRP levels.

Several things beyond infection can alter the levels of CRP in the blood. Pregnant women and women on hormonal birth control tend to have higher levels, as do people who consume a high amount of dietary fat. Liver disease can change CRP levels, since the liver is a major producer of this protein. When abnormal C-reactive protein levels are found during a blood screening, the patient may be interviewed to rule out these causes.

Studies on this protein have suggested that certain diseases can leave telltale sugars bound to CRP, sort of like fingerprints. Theoretically, it should be possible to test the protein for presence of particular sugars which could be used to identify a specific disease, although this would require very specialized equipment. More generally, a high level of this protein suggests that a patient is coping with infection somewhere in his or her body.

Naturally, CRP is present in trace amounts in the blood. Using highly sensitive tests, doctors can look for the slightly elevated levels which have been linked with high blood pressure, heart disease, and diabetes. The presence of higher levels can indicate that a patient is at greater risk of developing these medical conditions. If a patient takes a highly sensitive test which does reveal high levels, a doctor may make recommendations to help minimize the patient's risk, such as making changes to diet and exercise programs.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a WiseGeek researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments
By Clairdelune — On Sep 08, 2011

@BoniJ - Yes, C-reactive protein tests are usually given when you have a physical examination. Blood is taken at the same time that it is taken for a cholesterol test.

Many times a doctor can't really tell where the problem is within your body, if your level of CRP is on the high side. But a high level is often related to risk for heart problems, high blood pressure, and diabetes, among other possibilities.

After a doctor tests for those ailments there are tests for, better nutrition, more exercise and less stress in your lifestyle would be suggested by the doctor.

By BoniJ — On Sep 07, 2011

Are patients who go in for physical examination routinely tested for C- reactive protein? I can't remember having seen this test on my lab report.

It seems like it is a very important test. If you are in the normal range of CRP, there is probably no major inflammation or infection going on in your body. But if you are in the higher range, it might be a little difficult to pinpoint what is going on that is causing the the level of the protein to be too high.

Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

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