We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Abdallat Davis Farrage Syndrome?

Mary McMahon
Updated Jan 25, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Abdallat Davis Farrage syndrome is an extremely rare genetic condition that was first identified and described in 1980. It is characterized by pigmentation irregularities in the skin and nervous system problems. The condition is named for the team of medical professionals who first wrote it up, describing the appearance of the syndrome in a family from Jordan. It manifested in two brothers and a sister who were the children of first cousins who had married, suggesting a strong genetic link, and later testing did indeed reveal that the condition is genetic in nature.

This condition is a recessive trait, meaning that in order to manifest symptoms, someone must inherit a gene for Abdallat Davis Farrage syndrome from both parents. It is also autosomal, not linked to either of the genes that determine gender, so it can manifest in both men and women. People with only one gene are carriers, and they typically manifest no symptoms; in the event that someone inherits both genes, symptoms usually appear before one year of age.

A multitude of symptoms are associated with Abdallat Davis Farrage syndrome, but it is fundamentally classified as a form of phakomatosis, meaning that it is a disease of the central nervous system which is accompanied with skin abnormalities. It's also known as “neurocutaneous syndrome, Abdallat type,” referencing the neurological and skin problems associated with patients who have inherited both genes for the syndrome.

The skin problems associated with this condition include albinism, splotches or irregular pigmentation on the skin, and increased freckling. Many patients also exhibit unusual hair color, as part of the albinism. The central nervous system problems of Abdallat Davis Farrage syndrome patients cause them to experience extreme impairment in their extremities, including weakness in the arms and legs known as spastic paraparesis, and they tend to have a lack of sensitivity to pain, which can be problematic. Most experience peripheral neuropathy, a slow and steady degeneration of their peripheral nerves.

As yet, there is no treatment for Abdallat Davis Farrage syndrome. Care for patients usually focuses on keeping them comfortable and enabling them to live as normally as possible. Like other recessive traits, the condition can be brought out through intermarriage within an extended family. Many nations specifically ban such marriages for this very reason, and in regions where marriage within the family is not banned, people may want to think carefully about the consequences of a cousin marriage, as it greatly increases the risk for passing on dangerous genetic traits.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a WiseGeek researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments
Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

Learn more
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.