We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Factors Affect Sufficient Aminoglycoside Dosing?

By Maggie J. Hall
Updated Feb 11, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Aminoglycoside dosing depends on many variables that include the location of infection treated, along with the age and health of the patient. As side effects of aminoglycosides include possible hearing loss and kidney damage, physicians usually only prescribe this type of antibiotic under circumstances in which alternative medications prove ineffective. Different medications within the classification require different dosages.

The antibiotic group of medications known as aminoglycosides generally destroys bacteria by first compromising the microbe's membrane. After gaining entry into the cell, the drug inhibits protein synthesis by interfering with the 30S ribosome of the genetic material. Researchers also believe that once exposed to aminoglycosides, the body's phagocytic immune cells become more effective at destroying invading bacteria. Aminoglycosides are usually effective in eradicating strains of gram-positive staphylococcus and many gram-negative microbes, including E. coli and salmonella. Aminoglycosides are also effective agents for treating certain types of intestinal bacteria.

Uses of aminoglycosides include the treatment of bone or skin infections, respiratory or urinary tract infections, and infections involving the heart, also called carditis. Doses typically vary among the different aminoglycosides, which include amikacin, gentamicin and tobramycin. In most situations, physicians calculate aminoglycoside dosing for intramuscular (IM) or intravenous (IV) injections as these medications are generally not well absorbed when taken orally. Physicians typically prescribe amikacin at 7.5 mg/kg of body weight, once a day while gentamicin requires a dose of only 2 to 3 mg/kg once a day.

The dose for inhaled gentimicin is 20 mg twice a day, and tobramycin requires 300 mg inhaled twice a day when used for treating respiratory infections. Physicians may prescribe as much as 1,000 mg of an aminoglycoside before abdominal surgeries, to eliminate bacteria commonly found in the gastrointestinal tract. The doses of aminoglycosides generally differ for pediatric and adult patients. Elderly patients require aminoglycoside dosing adjustments as they do not typically eliminate the medication as quickly as younger patients, which may increase the risk of side effects.

If patients with renal, or kidney, insufficiency require this antibiotic, aminoglycoside dosing adjustments may also be necessary. Physicians usually monitor kidney function with blood tests that measure creatinine levels, when patients with renal disease take aminoglycosides, the drug causes cellular destruction in the glomeruli and small tubules of the kidneys. Symptoms associated with kidney impairment might include decreased urine output. Insufficient hydration, taking loop diuretics like furosemide or non-steroidal anti-inflammatory medications while using aminoglycosides also increases the risk of adverse effects.

Another serious side effect of aminoglycosides includes the possibility of developing varying degrees of hearing loss. The medication accumulates in the inner ear and gradually destroys the cells of the fine hairs that stimulate nerves and enable hearing. Patients may initially experience high frequency hearing loss followed by dizziness and nausea as more hair cells extending into more structures become affected. The condition is irreversible and usually requires cochlear implants to correct.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.