We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What are Sulfa Drugs?

Mary McMahon
Updated Feb 06, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Sulfa drugs are drugs which are derived from sulfanilamide. They were originally developed for use in treating bacterial infections and have since been applied to other medical uses as well. These drugs are not as widely prescribed as they once were because other drugs are more effective, some organisms have developed resistance to sulfa drugs, and a not insignificant number of the population is allergic to them. People with a sulfa allergy are not, however, allergic to sulfites and sulfates, along with other compounds which contain sulfur.

The first sulfa drug was discovered in 1932 and it laid the groundwork for a pharmaceutical revolution. Prior to the introduction of these drugs, people could die from bacterial infections which are today viewed as routine, because no drugs were available to treat them (penicillin was discovered earlier, but the medical applications of the drug were not realized until after sulfa had been introduced). The first sulfa drug spurred a number of competing companies to develop their own, leading to the widespread availability of such drugs just in time for the Second World War.

These drugs also triggered another revolution in the pharmaceutical industry: Tighter regulation of drug quality and purity. This unfortunately occurred in response to an incident in which numerous patients were poisoned by an impure batch of sulfa.

Sulfa drugs do not kill bacteria. Instead, they inhibit bacterial growth. When bacteria are exposed to the drugs, their uptake of folic acid is inhibited. This in turn prevents bacteria from reproducing. Today, antibiotics, drugs which actually kill bacteria, are generally preferred to sulfa drugs, although there are some conditions such as urinary tract infections for which these drugs will be prescribed.

Because of the allergy concerns, people with a history of reaction to sulfa drugs should make sure that it is noted in their charts. If a patient is prescribed a sulfa drug and begins to experience complications and side effects, these should be reported to a doctor. The doctor may recommend cessation of the drug and treatment with an alternative medication. People should also be aware that while many of these drugs contain “sulf-” in their names and are also labeled specifically with bold warnings due to allergy concerns, this is not the case with all such medications, and pharmacists should be alerted to drug allergies so that they can confirm the safety of any prescribed medications.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a WiseGeek researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments
By StealthyChamp — On Dec 10, 2013

Sulfa drugs were observed by German bacteriologist and pathologist, Gerhard Domagk.

Use of sulfonamides was prevalent during World War II. If you've seen any Word War II movie, you've seen a medic pouring a white powder over an open wound. That is a sulfonamide powder, which was standard in every first aid kit.

They are said to be credited with saving the lives of tens of thousands of patients, including Winston Churchill.

Mary McMahon
Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

Learn more
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.