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What Is Inhibin B?

Bobbie Fredericks
Bobbie Fredericks

Inhibin B is a protein hormone that acts as a feedback regulator for the production of follicle-stimulating hormone, or FSH. Both men and women produce inhibin B, but in different ways. FSH is produced by the anterior pituitary gland, and stimulates the production of sperm and maturation of eggs.

In women, FSH is produced during the first half of the menstrual cycle. This gears up the maturation of an egg, which will be released during ovulation, in the middle of the cycle. It also spurs the production of the hormone estradiol. Follicular granulosa cells in the ovaries then produce inhibin B so the pituitary gland will know the process has started and stop producing FSH.

There is a possible link between inhibin A and stillbirth.
There is a possible link between inhibin A and stillbirth.

As women reach menopause, inhibin B production decreases with the level of eggs that are available for fertilization, or ovarian reserve. The level of inhibin B in women can be used to determine fertility. Women with low levels of inhibin B on the third day of the menstrual cycle may not ovulate regularly.

Inhibin B production in men is by the Sertoli cells. FSH is produced by men to stimulate the production of sperm. Inhibin B regulates the FSH to keep sperm production within normal levels. Male fertility can also be assessed with an inhibin B test. Men with lower levels are often less fertile.

FSH is a substance produced in the pituitary gland, a gland at the base of the brain.
FSH is a substance produced in the pituitary gland, a gland at the base of the brain.

There are also some tumors that secrete inhibin B, so high levels may indicate that they are present. Granulosa cell tumors and epithelial tumors of the ovaries are such tumors. Patients with these forms may have their inhibin levels checked to monitor their condition. Postmenopausal women who have a detectable level of inhibin may have one of the tumors.

Follicular granulosa cells in the ovaries produce inhibin B so the pituitary gland will stop producing FSH.
Follicular granulosa cells in the ovaries produce inhibin B so the pituitary gland will stop producing FSH.

Another inhibin, inhibin A, can have the same effects on FSH. It is produced at a different time in the menstrual cycle. Inhibin A is also produced by the placenta during pregnancy. The measurement of inhibin A in the blood, along with the levels of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol during pregnancy can help determine the risk of down syndrome in the fetus. This is called a quad screen.

Women who have experienced a stillbirth may benefit from counseling.
Women who have experienced a stillbirth may benefit from counseling.

There is a possible link between inhibin A and stillbirth. One study found that women who experienced stillbirth had elevated levels of inhibin A during the second or third trimester of pregnancy. The numbers used were found via the quad screen for down syndrome, and those who experienced stillbirth had elevated levels of inhibin A only.

Discussion Comments

jennythelib

@MrsWinslow - I actually researched this for you because I'm trying to get better informed about the menstrual cycle and besides, it's what I do! (I'm a librarian.)

You have it just right. Inhibin B suppresses FSH production. What happens early on is that follicle-stimulating hormone is produced by the pituitary gland. Rising levels of FSH stimulate the production of inhibin a and b, which are produced in the ovaries. Rising levels of inhibin then signal the pituitary to stop making FSH, and the levels fall.

At menopause, obviously your ovaries stop working as well. So there's less inhibin, and that's apparently why your FSH levels rise out of control.

fredericks

Sorry, I wrote that wrong. It is FSH that suppresses inhibin B, not the other way around. So as FSH rises, inhibin B falls.

fredericks

An increase in inhibin B causes a decrease in FSH, while a decrease in inhibin B causes an increase in FSH. They go in opposite directions with the movement of inhibin B causing the movement of FSH. I hope this answers your questions, and good luck with your fertility.

MrsWinslow

What does a "feedback regulator" mean? I get that your inhibin B falls with ovarian reserve. But doesn't FSH actually *rise* as your ovarian reserve drops?

So do levels of follicle-stimulating hormone and inhibin B go in opposite directions? I.e., if inhibin B goes up, FSH goes down? (I guess that would explain its name; sounds like it inhibits something!)

Hoping for more insight on inhibin B levels and fertility. I'm thirty-five and I PCOS (polycystic ovarian syndrome), so all this is pretty important to me!

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    • There is a possible link between inhibin A and stillbirth.
      By: Monkey Business
      There is a possible link between inhibin A and stillbirth.
    • FSH is a substance produced in the pituitary gland, a gland at the base of the brain.
      By: 7activestudio
      FSH is a substance produced in the pituitary gland, a gland at the base of the brain.
    • Follicular granulosa cells in the ovaries produce inhibin B so the pituitary gland will stop producing FSH.
      By: pankajstock123
      Follicular granulosa cells in the ovaries produce inhibin B so the pituitary gland will stop producing FSH.
    • Women who have experienced a stillbirth may benefit from counseling.
      By: Monkey Business
      Women who have experienced a stillbirth may benefit from counseling.
    • In women, FSH is produced during the first half of the menstrual cycle.
      By: blueringmedia
      In women, FSH is produced during the first half of the menstrual cycle.
    • Higher levels of inhibin B in males has been associated with fertility.
      By: WavebreakMediaMicro
      Higher levels of inhibin B in males has been associated with fertility.